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Rationale Mycobacterium abscessus is a significant threat to individuals with cystic fibrosis (CF) due to innate drug resistance and potential transmission between patients. Recent studies described global dominant circulating clones of M. abscessus, but detailed genomic surveys have not yet been described for the United States (US). Objectives We examined the genetic diversity of respiratory M. abscessus isolates from US patients with CF and evaluated the potential for transmission events within CF Care Centers. Methods Whole genome

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Analyses of the expression of IHC markers were attempted between the PBC and their corresponding synchronous MALN and classified as concordant or discordant. Results were subjected to statistical analysis. Results Substantial agreement was observed for biomarker ER, PR, HER2/neu, p53, and Ki67 expression between PBC and MALN with k-value 0.79, 0.75, 0.89, 0.7, and 0.6, respectively. Conclusion There was high concordance for the IHC markers ER, PR, HER2/neu, p53, and Ki67 expression in matched pairs of PBC and corresponding synchronous M