https://www.selleckchem.com/pr....oducts/oicr-9429.htm
The C-3',4'-dideoxygenation structure in gentamicin can prevent deactivation by aminoglycoside 3'-phosphotransferase (APH(3') in drug-resistant pathogens. However, the enzyme catalyzing the dideoxygenation step in the gentamicin biosynthesis pathway remains unknown. Here, we report that GenP catalyzes 3' phosphorylation of the gentamicin biosynthesis intermediates JI-20A, JI-20Ba, and JI-20B. We further demonstrate that the pyridoxal-5'-phosphate (PLP)-dependent enzyme GenB3 uses these phosphorylated substrates to form 3',4'-dideoxy-

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How to Repair a Dead Car Key Sometimes extreme heat or cold can cause the car key to not function properly. You should wait a while before you decide to replace it. It's a real pain when the keys to your car break, and it happens at the most inconvenient times! You can repair a broken key without having to buy another one. Dead Key Fob Battery Modern key fobs allow us to open trunks, doors and tailgates without having to fumble around for a physical key. Some key fobs have an inbuilt key that can be used to start our vehicles. These fobs