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After that, CRS water content and collagen measurements were performed in the photoexposed dorsal as well as the photoprotected volar dermis of the subjects. A positive correlation of water content in the dermis with age could be confirmed (r=.55. Further, a positive correlation between water content of dorsal dermis and photoaging ranks was observed (Pearson's r=.417). Assessment of water content in the dermis with confocal Raman spectroscopy was found to be a promising method to measure the degree of photoaging in human subjects in