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We evaluated neurologic deficits by neurobehavioral examinations and blood-brain buffer disturbance by SPECT/CT imaging after injection of 99mTc-DTPA, an imaging marker of blood-brain buffer permeability. Outcomes In CKD rats, we found cognitive impairment when you look at the novel object recognition test, the object area task, and social memory examinations and an increase of blood-brain barrier permeability involving renal disorder. We found an important correlation between 99mTc-DTPA content in mind