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Adoptive T cell therapy (ACT) using either chimeric antigen receptor (CAR)- or T cell receptor (TCR)-engineered lymphocytes has emerged as a promising strategy to treat cancer. However, this therapy is still facing enormous challenges such as poor quality of autologous T cells, T cell exhaustion, and the immune suppressive tumor microenvironments. Additionally, graft-versus-host disease is an issue that must be addressed to allow the use of allogeneic T cells. Strategies to overcome these therapeutic challenges using gene editing te

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The lattice compressibility and deformation in superhard tungsten tetraboride (WB4) solid solution with chromium (Cr) are investigated by high-pressure x-ray diffraction and x-ray absorption fine structure (XAFS) spectroscopy up to 54 GPa. In contrast to pure WB4, the c-axis softening is effectively suppressed in W0.9Cr0.1B4, and less compressibility is shown for the a- and c-axes in the entire pressure range. Meanwhile, the white-line peak of W L3-edge XAFS in W0.9Cr0.1B4shows an absence of the sudden intensity drop as previously observ