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The results showed that the levels of leptin and non-HMW adiponectin were significantly higher in CRC patients compared with the controls (P0.05). In conclusion, higher leptin and non-HMW adiponectin levels may be associated with increased CRC. Chemotherapy may positively influence the levels of HMW adiponectin. No association between LEPR (rs6588147), ADIPO (rs266729), LEP (rs216727 and ADIPO (rs822369) polymorphisms with CRC was found.The aim of the present study was to evaluate the effects of switching to tenofovir alafenamide (

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