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RESULTS UV-B irradiation leads to a pronounced delay in circadian clock and downstream gene expression which interferes in the proper function of epidermal stem cells and as thus skin function. The use of a cosmetic active ingredient prevents cyclobutane pyrimidine dimer formation, protects epidermal stem cells and resets the circadian gene expression. It preserves the circadian changes in skin hydration, reduces daily fluctuations of skin redness and strengthens the skin barrier. CONCLUSION The skin has its own circadian biorhythm to g