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r of pregnancy is linked with a lower placental iodine load. Furthermore, the effect of air pollution on cord blood FT4 levels was partially mediated by the placental iodine load.Gout is the most common inflammatory arthritis in adults. It is causally associated with intraarticular deposition of monosodium urate crystals in hyperuricemia. The commonest pathogenesis is renal under-excretion of urate in metabolic syndrome. Despite being the commonest type, the exact etiology of hyperuricemia in metabolic syndrome remains unclear. Historic

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fying potential P-gp inhibitors in Traditional Chinese Medicine Systems Pharmacology (TCMSP) database containing a total of 13 051 unique compounds from 498 herbs, resulting in 875 potential P-gp inhibitors and 15 inhibitor-rich herbs. These predictions were partly supported by a literature search and are valuable not only to develop novel P-gp inhibitors from TCM in the early stages of drug development, but also to optimize the use of herbal remedies.Plasma membrane monoamine transporter (PMAT) is a polyspecific organi