https://www.selleckchem.com/pr....oducts/emd-1214063.h
Optimal analgesic treatment following cardiac surgery is crucial for both patient comfort and successful postoperative recovery. While knowledge of both the pharmacokinetics and pharmacodynamics of analgesics is required to predict optimal drug dosing, models quantifying the pharmacodynamics are scarce. Here, we quantify the pharmacodynamics of morphine by modeling the need for rescue morphine to treat unacceptable pain in 118 patients after cardiac surgery. The rescue morphine event data were analyzed with repeated time-to-event (R

https://www.selleckchem.com/pr....oducts/stat3-in-1.ht
The results show that the original samples exhibit low permeability. As the acidification time increases, the permeability of all of the samples shows an increasing trend, and the acid sensitivity index I a increases rapidly first and then levels off, and finally approaches 1. After 48 h of acidification, the samples show an increase ranging from 8.75 to 22.67 times (avg. 14.3 times) the original permeability. The permeability enhancement of the SQB anthracites is mainly attributed to the dissolution of acid-soluble minerals in the c