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These hydrogels are shown to possess material properties and resistance to enzymatic degradation that are comparable or superior to a type I collagen control. Moreover, such hydrogels containing the constructs with the RGD integrin-binding sequence are shown to promote the adhesion, spreading, and proliferation of C2C12 and 3T3 cells in vitro. Due to its enhanced solubility, structural stability, fluidity at elevated concentrations, ease of modification, and facility of cross-linking, this eBCL collagen-mimetic system has potential f

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Few academic historians take an evolutionary perspective on the past, but this outcome was not inevitable. Leading eighteenth-century intellectuals often took evolutionary perspectives, but particularists largely discredited them in and after the 1780s. By the time Spencer and Darwin revived evolutionism in the 1850s, distinctive historical questions and methods were very well-established. Public intellectuals regularly called for Darwinian history, but almost no academics saw much to gain in it. Most twentieth-century social scientists