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increase in the CCND1 copy number can induce high cyclin D1 protein expression in acral melanomas. However low-level increase and normal CCND1 copy number have no obvious correlation with protein expression. Cyclin D1 IHC cannot serve as a surrogate for CCND1 FISH in acral melanomas. Psoriasis is an autoimmune inflammatory skin disease that affects 0.5-3% of the world's population and current treatment options are posed with limitations. The reduced risk of failure in clinical trials for repositioned drug candidates and th