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2, CI [0.3-4.0], P = 0.8 and HR 1.7, CI [0.7-4.3], p = 0.2 for OS and PFS, respectively; LND cohort HR 3.1, CI [1.4-6.5], p 0.001 and HR 2.5, CI [1.2-4.9], p = 0.01 for OS and PFS, respectively). The prognostic value of LVSI disappears when patients undergo staging with SLN and are found to have negative nodes in contrast to those who have undergone LND. Future studies should confirm our observation on patients with negative sentinel nodes, and plan on tailoring adjuvant treatment to this specific subgroup. The prognostic value of L