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No DLTs occurred, and MTD was DL 2. Most common toxicities with TVEC were fever ( = 8), chills ( = 3), hematomas ( = 3), and injection site pain ( = 3). Thromboembolic events ( = 2) and bradycardia ( = 1) occurred during or after NAC. Five patients (55%) achieved RCB0, 2 had RCB1 (22%), and 2 had RCB2 (22%). The addition of TVEC to NAC was feasible at the approved dose, with manageable toxicity. The complete response rate was 55%. The addition of TVEC to NAC was feasible at the approved dose, with manageable toxicity. The complete response rate was 55%.Earl

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the most desirable delivery method, followed by in-person and video education. Burn patients reported variable pain experiences and a strong desire to receive additional pain education. This project informs key strategies to educate burn patients on pain leverage the high-level of interest in pain to foster education, describe pharmacologic and alternative therapies, offer weaning plans and explanation of addiction risks. Burn patients' perspectives help inform strategies and content creation for pain-related education materials that burn