https://www.selleckchem.com/pr....oducts/sch-900776.ht
BACKGROUND When proliferating tumor cells expand to areas distant from vascular sites, poor diffusion of oxygen and nutrients occur, generating a restrictive hypoxic gradient in which susceptible tumor cells die. The heterogeneous population surviving hypoxia and metabolic starvation include de-differentiated cancer stem cells (CSC), capable of self-renewing tumor-initiating cells (TICs), or those that divide asymmetrically to produce non-tumor-initiating differentiated (NTI-D) cell progeny. Under such restrictive conditions, both po

https://www.selleckchem.com/pr....oducts/iacs-010759-i
uggests the field may lack transparent reporting of technology development and implementation activities that could aid further decision-making. Beck-Fahrner syndrome is caused by homozygous or heterozygous mutations in TET3 on chromosome 2p13. The general characteristics of this syndrome include behavioral abnormalities such as autistic features, attention-deficit hyperactivity disorder, learning disabilities, and epilepsy. Six years old male patient was found to have a de novo TET3 loss-of-function variant by whole-exom