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Edaravone (Eda) is a free radical scavenger used in clinical trials for the treatment of ischemic stroke and amyotrophic lateral sclerosis. However, how Eda exerts its neuroprotective effects remains to be elucidated. We investigated the neuroprotective effects of Eda in cultured hippocampal neurons and in a mouse model of AlCl3/D-galactose-induced cognitive impairment. Eda protected hippocampal neurons by eliminating H2O2 or glutamate-induced toxicity, leading to decreased cell viability and neurite shortening. Consistently, Eda restore
Green Borneo Kratom is sourced from the deep forests of Borneo, where the rich soil and humid climate produce some of the strongest kratom leaves in the world. This green-vein variety is known for offering the “best of both worlds”—a perfect balance between stimulating and calming effects.