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The developed fibrous scaffold may provide structural, compositional, and chemical gradients for bone regeneration. BRIEFS Structural and chemical gradient fibrous scaffold fabricated by co-electrospinning.Bone cements with the feature of easily shaping could ideally match the defect site and prevent the ingrowth of fibrous tissue. In this manuscript, a biodegradable tricalcium silicate (C3S)/glucono-delta-lactone (GDL)/calcium sulfate dihydrate (CSD) organic-inorganic composite cement was fabricated with shorter setting time (less than

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