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9%) with a total of 553 pDDIs. From all 417 rDDIs, 43.2% (n = 18 were associated with lopinavir/ritonavir and 52.9% (n = 221) with hydroxychloroquine, both of them the most prescribed (106 and 165 patients, respectively). The main mechanism of interaction observed was QTc prolongation. Clinically relevant rDDIs were identified among 81.1% (n = 338) ('potential interactions' and 14.6% (n = 61) (contraindicated) of the patients. Charlson index (OR 1.34, 95% IC 1.02-1.76) and number of drugs prescribed during admission (OR 1.42, 95% I

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Strong consideration should be given to the placement of SSCs on primary molars in patients with early childhood caries under general anesthesia. Placement of primary molar SSCs during initial treatment under general anesthesia may reduce the need for additional treatment in the future.Purpose Casein phosphopeptide amorphous calcium phosphate fluoride varnish (commercially available as MI Varnish®) is a promising minimally invasive remineralizing agent. The purpose of this study was to compare the effectiveness of intensive application of