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The results of this study confirmed that treatment with Fenugreek seeds extract successively ameliorates the altered glucose and lipid profile in liver damage induced by thioacetamide in male rats.The detoxification effects of licorice are believed to be related to its pharmacokinetic (PK) interference. This paper aimed to evaluate the effects of licorice water extracts (LWE) on the pharmacokinetics of brucine. Rats were administered brucine and/or LWE. The pharmacokinetic behavior of brucine and bioactive components of licorice were qu