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Overproduction of reactive oxygen species (ROS) and swelling are a couple of key pathogeneses of noise-induced hearing loss (NIHL), leading to exterior hair cell (OHC) damage and hearing reduction. In this work, we successfully developed ROS-responsive nanoparticles as berberine (BBR) providers (PL-PPS/BBR) for OHC-targeted treatment of NIHL Prestin-targeting peptide 2 (PrTP2)-modified nanoparticles (PL-PPS/BBR), which successfully gather

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