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Low brain tissue oxygen tension (PbtO ) has been shown to be an independent factor associated with unfavourable outcomes in traumatic brain injury (TBI). Although PbtO provides clinicians with an understanding of ischaemic and non-ischaemic derangements of brain physiology, the value alone can be the result of several factors, including partial arterial oxygenation pressure (PaO ), haemoglobin levels (Hb) and cerebral perfusion pressure (CPP). This chapter presents a single-centre, retrospective cohort study of 70 adult patients with