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Spiritual well-being (SW is significant for patients with life-limiting illnesses. Thus, shortened versions of questions would be helpful in approaching SWB. Our goal was to develop a one-item screening question to assess the SWB of advanced cancer inpatients. This was a cross-sectional, multicenter study involving adult advanced cancer inpatients from seven palliative care units in South Korea. The candidate one-item questions were three questions scored using numeric rating scales from 0 to 10 feeling at peace (Are you at peace