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8 % - 118.0 % and RSDs less than 9.5 %. The results demonstrate that the SNW-1 shows great potential for the enrichment of trace SAs in complex matrices.Buffer preparation and storage requires a significant facility footprint in large scale bioprocessing and together with the costs of supply chain management can have a substantial economic impact. In-line buffer mixing in chromatography is commonly performed by blending different buffer solutions using at least two pumps and a static or dynamic mixer. We developed a device f