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f MET-1 supernatant and lipopolysaccharide (LPS) from Escherichia coli 05B5 on NG neuron excitability. LPS increased the excitability of NG neurons in a toll like receptor 4 (TLR4 )-dependent and PAR2 -independent manner, whereas the excitatory effects of MET-1 supernatant were independent of TLR4 activation. Together, our findings suggest that cysteine proteases from commensal bacteria increase the excitability of vagal afferent neurons by the activation of PAR2 . This article is protected by copyright. All rights reserved. This article
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