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Conversely, in placebo-treated patients no modifications of biomarkers were evaluated at T1. CONCLUSION Present laboratory data rely on the anti-oxidant, anti-inflammatory and anti-allergic properties of polyphenols. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.AIMS The present study aims at analyzing CU score with respect to time, as a time-series. We have attempted to model the investigated time-series in order to unravel possible causative relationships. BACKGROUND Chronic spontaneo