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for the early diagnosis and prognosis monitoring of ESCC. CircRNAs can be used as promising molecular biomarkers for the early diagnosis and prognosis monitoring of ESCC.In the phase III RESTORE-IMI 2 study (ClinicalTrials.gov NCT02493764), the combination antibacterial agent imipenem/cilastatin/relebactam (IMI/REL) demonstrated noninferiority to piperacillin/tazobactam for the end points of all-cause mortality at day 28 and favorable clinical response at the early follow-up visit in adult participants with gram-negative hospital-acquir