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Special attention is required in the root canal treatment of mandibular incisors, especially in patients aged above 21 years. To investigate whether the levels of serum C-reactive protein (CRP), salivary interleukin (IL)-6 and IL-lβ in metabolic syndrome (MS) patients can be potential monitors for inflammation in MS patients with severe periodontitis. A total of 114 MS patients and 49 systemically healthy subjects were enrolled. CRP in serum and IL-1β and IL-6 in non-stimulated whole saliva were collected from these patients an