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Several Ca2+-permeable cation channels attract attention for their mechanotransducer function to evoke Ca2+ signals in cell invasion. Vellino et al., have clarified the versatility of the osmo-sensing TRPV4 channel in regulating invadosome functions TRPV4 detects and integrates multiple cellular and environmental cues, triggering Ca2+ signals and molecular interactions that modulate coupling between acto-adhesion and extracellular matrix degradation.Phase-contrast magnetic resonance velocimetry (PC-MRI) has been widely used to investi