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This is the first attempt to show that non-invasive MRI biomarkers are linked to AD progression characteristics, reinforcing their use in early AD diagnosis and monitoring. Most individuals with Down syndrome (DS) have the neuropathological changes of Alzheimer's disease (AD) by age 40 and will have developed dementia by age 60. Alterations of the intrinsic connectivity of the default mode network (DMN) are associated with AD in the neurotypical population. In this study, we sought to determine whether, and how, connectivity betwe

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How to Choose the Best Double Mattress The mattress you choose can be a major influence on your sleeping position, health and comfort. The mattress you select should fit your sleeping style and your body weight. The top double mattresses have a firmness that is suitable for all body types and sleep positions. It also offers support and pressure relief for your back. Firmness The quality of a mattress's