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Melanoma is inherently heterogeneous, providing resistance to apoptosis. Anoikis resistance is a hallmark feature of metastatic melanoma to escape apoptosis when cells lose contact with adjacent cells or extracellular matrix. The yes-associated protein transcription co-activator is the effector of Hippo pathway. Herein, we investigated the function of yes-associated protein in anoikis resistance of melanoma cells. When melanoma cells were grown under anchorage-independent condition, anoikis-resistant cells displayed higher levels of yes-

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Showed that at 24 h after direct contact with composite scaffold, all scaffolds showed proliferation of cells 50% and increased in cell density on day 7. The scaffold of the highest percentage of CeO in bioactive glass nanoparticles (sample CL/CH/C1 showed the lowest inhibition of cell proliferation ( 25%) at day 7. Moreover, the indirect cell viability test showed that all extracts from the four composite scaffolds did not demonstrate a toxic effect on the cells (inhibition value 25%). The addition of CeO to the glass c