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In this study, the numerical simulation of heat transfer of Al2O3-water nanofluid in a pipe equipped with helically twisted tapes is investigated. The volume fraction of nanoparticles in this study is equal to 0, 1, 2, and 3%, and a two-phase mixture method has been used to simulate the nanofluids. The flow regime is laminar in the present study, and Reynolds numbers are Re = 250, 500, 750, and 1000. The helical twisted tapes are in three different types, single, double, and triple. The same heat flux 5000Wm-2 is applied to the walls. T

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