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Our findings suggested that CLIC4 could be involved in FxOH-induced apoptosis in human CRC.With the advent of the big data era, machine learning methods have evolved and proliferated. This study focused on penalized regression, a procedure that builds interpretive prediction models among machine learning methods. In particular, penalized regression coupled with large-scale data can explore hundreds or thousands of variables in one statistical model without convergence problems and identify yet uninvestigated impor

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Competitive displacement with SMVT-targets, such as biotin, lipoic acid or sodium pantothenate, showed Sq2B targeting ability to SMVT. This fluorogenic probe for biotin receptors could distinguish cancer cells (HeLa and K from model non-cancer cell lines (NIH/3T3 and HEK293T). The obtained results provide guidelines for development of new dimerization-based fluorogenic probes and propose bright tools for imaging biotin receptors, which is particularly important for specific detection of cancer cells.Organic structure-directing agents (