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Cyclin-dependent kinases (CDKs) tend to be serine/threonine kinases whose catalytic activities tend to be managed by communications with cyclins and CDK inhibitors (CKIs). CDKs are key regulating enzymes associated with cellular proliferation through regulating cell-cycle checkpoints and transcriptional activities in reaction to extracellular and intracellular indicators. Not surprisingly, the dysregulation of CDKs is a hallmark of types of cancer