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Our in vitro research results suggested that VIP presented BMSCs osteogenic differentiation by activating Wnt/β-catenin signaling pathway in BMSCs. VIP could also stimulate tube formation of EA.hy926 endothelial cell while increasing VEGF expression in BMSCs. Moreover, into the rat skull problem design, VIP-conjugated functionalized hydrogel considerably enhanced cranial bone tissue defect repair comparing into the control team, with additional bone tissue

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