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The tool collection was augmented by three tools StructureProfiler validates ligands and active internet sites making use of choice criteria of well-established protein-ligand benchmark data sets, WarPP places liquid molecules in the ligand binding internet sites of a protein, and METALizer calculates, predicts and ratings coordination geometries of material ions centered on surrounding complex atoms. Furthermore, all tools supplied by ProteinsPlus can be found through a REST service e