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Expression chip and RT-qPCR analysis indicated that knockdown of SND1 up-regulated the expression of senescence-associated secretory phenotype components (SASP). Conclusions Our data indicated that down-regulation of SND1 regulated human diploid cell senescence by up-regulating the expression of SASP components.Objective To investigate the expression of follistatin related gene ( FLRG) in colon cancer and its relationship with clinicopathological features of colon cancer. Methods The cancer tissue, paracancerous tissue and normal tissue