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To investigate the clinical relevance of germline SMARCB1 mutation in AT/RT patients, we performed sequence analysis of the coding regions. The two patients with AT/RT were found to have germline SMARCB1 mutations. No BRAF mutations were found, and only NTRK gene fusion was present in one patient. We also have examined the association with OS and PFS and different histological subtypes of infant CNS proving that high-grade astrocytoma has better overall survival than other tumor types (p 0.007 and p 0.059. Conclusion High-dose chemoth

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In patients with vaginismus, the treatment becomes more challenging and the treatment may take longer as the grade of vaginismus is higher or worsens. However, the differences regarding treatment duration, success, and treatment methods by grades are not evident in the literature. The aim of this study is to answer the question, "Does the number of treatment sessions, dilator requirement, treatment success, pre- post-treatment FSFI scores and obstetric results of vaginismus patients change depending on the vaginismus-grade?" The patients were divided i