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We explain NMR methods based on metabolically directed specific isotope labeling for the identification of molecular disorder and/or conformational transitions regarding the RNA backbone ribose groups. These analyses tend to be complemented by way of synthetic covalently altered nucleotides constrained to an individual sugar pucker, which enable practical evaluation of dynamics by selectively removing a small conformer identified by NMR through the architectural ensemble.Selective 2'-hydroxyl acy

https://www.selleckchem.com/pr....oducts/pclx-001-ddd8
This article is categorized under   Technologies Analysis of the Transcriptome.Redox regulation has recently been proposed as a critical intracellular mechanism affecting cell survival, proliferation, and differentiation. Redox homeostasis has also been implicated in a variety of degenerative neurological disorders such as Parkinson's and Alzheimer's disease. In fact, it is hypothesized that markers of oxidative stress precede pathologic lesions in Alzheimer's disease and other neurodegenerative diseases. Several therapeu