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Conclusions Four novel genes associated with AD pathogenesis were identified and validated, which provided novel therapeutic targets for AD. Amantadine has been shown to attenuate postoperative learning and memory dysfunction in young adult rats. However, postoperative cognitive dysfunction often occurs in elderly patients. We aimed to determine whether amantadine attenuated postoperative learning and memory dysfunction and whether these effects were associated with improved dendritic arborization in old rodents. Eighteen-month old male
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