https://www.selleckchem.com/pr....oducts/piperaquine-p
Effective and noninvasive cancer diagnosis is expected to ease the burden of continued increased deaths worldwide. Herein, we proposed viscosity of the tumor microenvironment as a biomarker and further develop a versatile optical agent, TBM-V, for monitoring tumor microenvironmental viscosity alterations to achieve cancer diagnosis, therapeutic effect tracking, and anticancer drug screening. When in highly viscous media, near-infrared signals of TBM-V are specifically activated, endowing the probe with the capacity of avoi

https://www.selleckchem.com/
Copper radical oxidases (CROs) from Auxiliary Activity Family 5, Subfamily 2 (AA5_2), are organic cofactor-free biocatalysts for the selective oxidation of alcohols to the corresponding aldehydes. AA5_2 CROs comprise canonical galactose-6-oxidases as well as the more recently discovered general alcohol oxidases and aryl alcohol oxidases. Guided by primary and tertiary protein structural analyses, we targeted a distinct extended loop in the active site of a Colletotrichum graminicola aryl alcohol oxidase (CgrAAO) to explore its effect on catalysis in the bro