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These results suggest a link between exercise intolerance and the decreased ability to produce force. Novelty bullets • We provided the first characterization of the effects of prolonged stretching on the metabolic response during severe cycling. • Stretching reduced maximal force, augmented muscle activation in turn increasing the metabolic response to sustain exercise.Despite the essential role that glycans play in many biological processes, their isomeric complexity makes their structural determination particularly challenging.

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