https://checkpointinhibitor.co....m/while-intricacy-th
Accumulation of aggregation-prone proteins, such as amyloid-β 42 (Aβ), α-synuclein, or mutant Cu/Zn-superoxide dismutase (SOD1), had been aggravated upon the knockdown of rme-8/DNAJC13 in C. elegans plus in human cellular outlines, respectively. DNAJC13 is involved with endosomal necessary protein trafficking and linked to the retromer and also the WASH complex. As both complexes have been associated with autophagy, we investigated the part of DNAJC13 in this degradative pathway. In knockdown a
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