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Deregulation of Cdt2 is clear in malignancies and ended up being recently highlighted as an important target of oncogenic viruses, giving support to the healing targeting regarding the ligase as a promising anticancer method. PURPOSE To identify risk aspects for developing symptomatic brain metastases and evaluate the impact of prophylactic cranial irradiation (PCI) on mind metastasis-free survival (BMFS) and general survival (OS) in extensive illness tiny cell lung cancer (ED-SCL