https://www.selleckchem.com/pr....oducts/pf-06882961.h
Introduction For many years, applications for baclofen have widened in the treatment of substance abuse disorder (SUD), mainly alcohol use disorder, with a growing rate of off-label prescriptions in Europe. Clinical effects seem to be both a decrease of craving and anxiety, leading to a decrease of drug or alcohol consumption. We described baclofen poisoning circumstances, therapeutic options and outcomes when used in substance use disorders.Areas covered This review summarizes the toxicological considerations where baclofen was pre

https://www.selleckchem.com/pr....oducts/gi254023x.htm
A novel, nonsurgical approach to interrupting the enterohepatic circulation is inhibition of the ileal bile acid transporter, a key molecule in the enterohepatic circulation that reabsorbs bile acids from the intestine. Ileal bile acid transport inhibition has been shown to reduce serum bile acids and pruritus in trials of pediatric cholestatic liver diseases. This review explores the rationale of inhibition of the ileal bile acid transporter as a therapeutic target, describes ileal bile acid transport inhibitors in development, and s