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Under poikilocapnic conditions neither facial cooling nor CPT evoked a change in middle cerebral artery blood flow velocity (MCA Vmean ; transcranial Doppler) (P 0.05 vs. baseline). Under isocapnic conditions, facial cooling did not change MCA Vmean (P 0.05), whereas CPT increased MCA Vmean by 13% (P 0.05). Finally, MCA Vmean and ICAQ were similarly increased by BH either with or without facial cooling. These findings suggest that physiological factors associated with BH, and not facial cooling (i.e., trigeminal nerve stimulatio

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