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Sciatic nerves of 8 M Dmdmdx rats had much more consistently increased levels of S100β and Tau5 proteins, weighed against 9 M mdx mice, encouraging pronounced dystropathology when you look at the rat model. There have been no variations for mRNA amounts, apart from higher gelsolin mRNA in Dmdmdx sciatic nerves. The pronounced necessary protein changes in Dmdmdx nerves indicate a severe continuous myonecrosis, and likely consequent myofibre denervation, for the dystrophic r
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