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Male ob/ob mice exhibited LVH, cardiac irritation, and oxidative tension. Using RNA-seq evaluation, we identified that an iron uptake-associated gene, transferrin receptor, was upregulated in overweight ob/ob mice with LVH. Caloric limitation attenuated myocyte hypertrophy, cardiac inflammation, fibrosis, and oxidative anxiety in ob/ob and db/db mice. Furthermore, we discovered that caloric constraint reversed iron homeostasis-related lipocalin 2, divalent metal transporter 1, transferrin receptor, ferritin, ferroportin, an