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Randomly chosen chest x-rays of public datasets were evaluated by 3 physicians and 1 thoracic radiologist. In comparison with the public datasets of NIH and CheXpert, where AUCs did not significantly drop to 16%, the AUC of the AMC-SNUBH dataset significantly decreased from 2% label noise. Evaluation of the public datasets by 3 physicians and 1 thoracic radiologist showed an accuracy of 65%-80%. The deep learning-based computer-aided diagnosis model is sensitive to label noise, and computer-aided diagnosis with inaccurate lab