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[This corrects the article DOI 10.3389/fimmu.2018.00473.]. Copyright © 2020 Tian, Ma, Wang, Tian, Zhang, Mao, Xu and Wang.Human herpesvirus (HHV)-6A or HHV-6B involvement in multiple sclerosis (MS) etiology has remained controversial mainly due to the lack of serological methods that can distinguish the two viruses. A novel multiplex serological assay measuring IgG reactivity against the immediate-early protein 1 from HHV-6A (IE1A) and HHV-6B (IE1 was used in a MS cohort (8,742 persons with MS and 7,215 matched controls), and a pre-M