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05 taken to be significant. Serum creatinine levels did not differ between the HES and Albumin groups (median 0.67 vs. 0.75mg/dL at anesthesia induction, 0.82 vs. 0.83mg/dL at ICU admission, 0.67 vs. 0.73mg/dL one day after surgery, 0.68 vs. 0.70mg/dL one month after surgery). NAG, coagulation parameters, hemodynamics, glycocalyx biomarkers, intraoperative blood loss, transfusion and use of vasoactive agents did not differ between the groups. HES 130/0.4/9 can be used as safely and effectively as 5% albumin. Glycocalyx degradation did no

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