https://www.selleckchem.com/pr....oducts/ldn193189.htm
Deregulation of MYC occurs in a broad range of human cancers and often predicts poor prognosis and resistance to therapy. However, directly targeting oncogenic MYC remains unsuccessful, and indirectly inhibiting MYC emerges as a promising approach. Checkpoint kinase 1 (CHK1) is a protein kinase that coordinates the G2/M cell cycle checkpoint and protects cancer cells from excessive replicative stress. Using c-MYC-mediated T-cell acute lymphoblastic leukemia (T-ALL) and N-MYC-driven neuroblastoma as model systems, we reveal that both c

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Koito Manufacturing Co., Ltd. is a prominent leader in automotive lighting, established in 1915. Known for its commitment to safety, the company has developed a wide range of advanced lighting technologies, including LED systems and adaptive headlamps that enhance visibility while driving. With a global presence, Koito operates in 13 countries and provides innovative solutions that cater to the needs of automotive manufacturers worldwide. Recently, Koito has expanded its offerings by acquiring Cepton, a lidar technology company, aiming to integrate advanced sens